Thursday, December 1, 2011
How To Spend To Save
1. Prepare your shopping list in advance.
2. Visit shopping mall with presence of both supermarket giants - Coles and Woolworths (see list further below).
3. Have quick tours of these supermarkets in turn, jot down (or memorise if you can) the lower prices between the two for the items you intend to buy.
4. Go to the first supermarket (e.g. Coles), select and buy those items with lower prices. Get the fuel discount voucher for further savings when you make the appropriate amount of purchase.
5. Unload bought items to your car in the car-park.
6. Go to the second supermarket (e.g. Woolworths), select and buy those items with lower prices. Get the fuel discount voucher for further savings when you make the appropriate amount of purchase.
7. Unload bought items to your car in the car-park and go home.
Following are the shopping malls in the Sydney metropolitan area with presence of both Coles and Woolworths. Surprisingly, the supermarkets are usually located fairly close to each other (as shopping malls usually set aside only certain region for groceries). As such, you don't have to spend too much extra of your time to compare prices between the two supermarkets. But the saving could be quite rewarding:
Bauulkham Hill - Stockland
Bondi Junction - Westfield
Brookvale - Warringah Mall
Burwood - Westfield
Campbelltown - Macquarie Square
Carlingford - Carlingford Court
East Garden - Westfield
Hornsby - Westfield
Liverpool - Westfield
Mt. Druitt - Westfield
Parramatta - Westfield
Rouse Hill - Rouse Hill Town Centre
Sylvania - Southgate Shopping Centre
Warriewood - Centro Warriwood
Happy shopping!
Wednesday, November 23, 2011
The Secrets of Life (4) - Faulty Genes and Close Relations Marriage
During the formation of the egg or sperm, the two legs of each of the 23 pairs of chromosomes separate. The egg or sperm then has only single legs of the 23 pairs of chromosomes. At the time of conception, the egg and the sperm combine to form the first cell of the child. Each leg of the egg will combine with its corresponding counterpart of the sperm forming 23 pairs of chromosomes like the parents. If there is a faulty gene in the chromosome of the egg, AND if there is a SAME faulty gene in the chromosome of the sperm, then the SAME copy of the genes in the chromosome will be faulty resulting in genetic problems in the child.
Given the facts that there are 25,000 - 35,000 genes in human, a healthy human usually has only a few faulty genes and the faulty genes exist randomly, the chance of having a SAME faulty gene during conception (hence causing genetic problems) of two UNRELATED individuals is extremely low. But when the two individuals are close blood relatives, they share a greater proportion of genes in common than unrelated individuals do because they have a common ancestor from whom they inherited their genes. As such, they have a greater chance of having a same faulty gene in common in their chromosomes. When their egg and sperm combine at time of conception, there is a greater risk of having a child with a same copy of faulty genes in the chromosomes and hence a greater risk of having genetic problems.
The table below shows the proportion of genes shared between close blood relatives:
| Relationship Type | Relationship | Proportion of Genes in Common |
|
| Twins (雙生兄妹, 姐弟) | All – 100% |
| First degree relatives | Brother and sister (兄妹, 姐弟) | Half – 50% |
| Second degree relatives | Half brother and sister (同父異母或同母異父兄妹, 姐弟) | Quarter – 25% |
| Third degree relatives | Cousins (堂兄妹, 姐弟, 表兄妹, 姐弟) | Eighth – 12.5% |
Thursday, November 17, 2011
How to Do a (Right) Research
The teacher asked his science students to research some of the latest and most amazing genetic developments using new biotechnology procedures.
Jim, Tom and Peter used Google as the search engine on the internet for their work. Jim presented a picture of a mouse with what looks like an human ear growing on its back. His source was from the BBC News. Tom found the same picture in Wikipedia and found it was the Vacanti Mouse. Peter found the same picture in Dr Karl's Great Moments in Science on ABC Science. Each boy used the information from Google to write up a report on the Vacanti Mouse.
While their effort on the research work were all commendable, only one was right!
The questions are:
1. Which boy got it right?
2. How, using the internet, can information be validated?
3. What does this mean for finding 'truth'?
BBC, Wikipedia and ABC are all reputable sources. But they provided different interpretations of this genetically engineered ear growing on the back of a mouse. Among them, the ABC Science program, Dr Karl's Great Moments in Science was correct ....... the others wrong.
So how was this determined?
The best (and correct) way is to go to the source of the work - in this case Dr Vacanti. Search for the original reports by Dr Vacanti, then consider the original reports with those given by sources like BBC, Wikipedia and ABC.
The key is to (try the best to) validate straight from the horse's mouth.
Monday, November 7, 2011
European Debt Crisis (3 of 3) - Solutions! or Solutions?
1. The European private banks holding Greek bonds agreed to write off 50% of their face value. Effectively, this will lower the Greek debts from the expected 180% to 120% of their GDP by 2020. Although the figure is still enormous but now is more sustainable for an economy driven into recession by austerity measures.
2. European banks will be required to raise about 106-billion euros in new capital by June 2012 to increase their holdings of safe assets to 9% of their total capital. This would help protect them against potential losses resulting from any government defaults, and hence avoid any potential bank crisis.
3. The main euro bailout fund - European Financial Stability Fund (EFSF) - will be expanded from 440-billion euros set up earlier this year to 1-trillion euros. This would be sufficient to provide guarantees for bonds issued by countries including Italy and Spain.
The first part provides a short-term action to alleviate Greek's debt burden. By having the European banks writing off 50% of their debts, it would give some breathing space for Greece for some time. But with the still staggering figure of 120% debt to GDP ratio (doubling the EU limit of 60%), coupled with the weakening economy due to the austerity measures imposed on the country in exchange of the EU bailout packages, will Greece be able to repay or reduce its debts by itself?
The second part aims to provide a medium-term firewall to protect European banks from any potential government defaults. However, this is just a target set by the EU leaders. No information is yet available on how to raise the 106-billion euro of fresh capital. Given the banks taking up 50% loss of their Greek bond assets in support of part 1, will the banks be able to further raise that level of capital by June, 2012?
The third part aims to provide a longer-term pool of fund to help bailout euro countries with financial difficulties, especially larger economies like Italy and Spain. But how to boost up the fund to 1-trillion euro is still yet unknown. The head of EFSF traveled to China right after the EU meeting on 26Oct to discuss on possibility of China's contribution as China is one of the few countries with good financial reserves. But will China be willing to invest in this risky business? China may ask for political returns in exchange of their financial contribution if they do invest. Will EU be able to accept? If not, where will the money come from? Further questions may also be asked. Is the 1-trillion euro fund enough given the (seemingly endless) bailouts needed for the debt countries? Is the continual bailout a right strategy to resolve the crisis?
The EU leaders, especially Germany and France, are very determined to maintain the integrity of the EU and the Eurozone. They worked very hard to try to keep Europe intact from disintegrating due to debt problems of eurozone members. They are very anxious and keen in implementing the plan agreed on 26 October, 2011 to resolve the crisis. But with the ever worsening situation in Europe, especially recently with Italy which is the third largest economy in eurozone after Germany and France - an economy too big to be saved, lining up to a brink of falling after Greece, can it really solve the crisis? If not, what are the real solutions?????
Only time will tell!
Sunday, November 6, 2011
European Debt Crisis (2) - How and When It Developed
Take Greece as an example. A job which pays 55,000 euros in Germany, pays 70,000 euros in Greece, despite Germany being a more productive country. To get around pay restraints in the calendar year, the Greek government simply paid employees a 13th and even 14th monthly salary. Furthermore, the Greek government categorizes certain jobs as arduous which have a retirement age of 55 for men and 50 for women with generous pensions. More than 600 Greek professions somehow managed to get themselves classified as arduous like hairdressers, radio announcers, musicians etc. All these goodies required substantial government funding which far exceeded their national income. Greece had to borrow money to pay for the expenditures via government bonds etc. As a result, national debts gradually built up.
On 1 January, 1999, the EU launched euro as its official currency. Most EU countries (called the eurozone) uses euro as a common currency among themselves. Before the euro, the PIIGS countries had to borrow money at interest rates much higher than the rates at which Germany paid since Germany was an economically better managed country and hence had a very good credit rating and enjoyed low interest rates. When these countries started to use the euro, they could borrow money at interest rates close to that of Germany. So taking advantage of the lower interest rates, they kept borrowing to buy stuffs that they couldn't afford.
Apart from the low interest rates, the inflation in the PIIGS countries was higher than the rate of interest. In simple terms, if the borrowing rate is 3% and the inflation is 5%, one can gain 2% by borrowing to buy things. So borrow and borrow they did. Over the years, PIIGS countries, especially Greece, amassed an enormous amount of debts in euros which then became unmanageable, and made the governments difficult, if not impossible, to repay.
As an indication of the problem, the following shows the deficit to GDP ratios and the debt to GDP ratios of the PIIGS countries (figures being 2010 estimates based on Eurostat - Apr11):
| Country | Deficit to GDP (%) | Debt to GDP (%) |
| Greece | 10.5 | 142.8 |
| Italy | 4.6 | 119 |
| Ireland | 32.4 | 96.2 |
| Portugal | 9.1 | 93 |
| Spain | 9.2 | 60.1 |
And so the problems went on, and finally became a crisis and brought to the world's focus at end 2009. Greece got the worst situation among others. The country hired Wall Street firms, most notably Goldman Sachs, to help hide its debt so as not to run afoul of EU rules. In December, 2009, Greece was forced to admit that its debts were much higher than previously estimated, reaching 300 billion euros, the highest in modern history. Rating agencies started to downgrade Greek banks and government bonds. In the following few months, Greece responded with a series of austerity programs sparkling serious strikes and riots in the streets. Greece's borrowing costs reached yet further record highs.
By May, 2010, euro members and the International Monetary Fund (IMF) provided a 110-billion euro bailout package to rescue Greece. The situation in Ireland also deteriorated, and in November, 2010, the EU and IMF provided a 85-billion euro bailout package to Ireland. Ireland soon passed the toughest budget in the country's history in return.
Attempting to stop the crisis from spreading, in February, 2011, eurozone leaders established a 500-billion European Financial Stability Fund (EFSF) to provide loans to any euro countries with financial difficulty. In April, 2011, Portugal asked for assistance and was provided with a 78-billion euro bailout package. In July, 2011, Greece passed another round of drastic austerity program, and was provided a second bailout package of 109-billion euros, sparkling even more serious civil unrest though.
While bailouts had so far only been provided to Greece, Ireland and Portugal, situations in Spain and Italy began to look worrying, with interests on government bonds rising sharply and credit ratings being downgraded. In September, 2011, Spain passed constitutional amendment to impose rule to keep future budget deficit to strict limit. Italy passed an austerity budget to balance the country's budget by 2013. Italy and Spain, being the third and fourth largest economies in eurozone after Germany and France, were then put under the world's spotlight.
In October, 2011, eurozone finance ministers approved another 8-billion bailout to Greece, which the country needs desperately before running out of cash by 15 December, 2011.
It now seems almost certain that Greece will not be able to repay its debts by itself. Situations in Ireland, Portugal, Spain and Italy are not too better off. Because of the continued downgraded credit ratings, these PIIGS countries find it harder and harder to borrow as lenders will charge more for further loans. Coupled with austerity measures that these countries must take in order to seek assistance from the EU, economies of these countries are contracting. Many European banks, as well as the European Central Bank, own bonds issued by these governments. Should any of them go default (Greece is the most likely one), many of those banks will have big losses. If some of Europe's biggest banks suddenly look dangerously weak, then other banks may hesitate to extend credit to each other, fearing they too could get dragged down. A banking crisis could begin, resulting in recessions in Europe.
The European problem could potentially spread across the Atlantic to the US because US money market funds hold substantial amount of short-term debts of European banks. If European banks can't find lenders to allow them to routinely issue short-term debts, financial markets could start to freeze up, causing turmoil in US money market funds. As the EU and the US are big economic partners, recession in Europe will ultimately lead to a recession in the US. Slower growth in the EU and the US will then hurt the Asian economies which depend on the West to buy their manufactured goods. As a result, the global economy could fall into a profound recession.
Friday, November 4, 2011
European Debt Crisis (1) - Formation of the European Union
Six years later in 1957, the 6 members further sought closer union and signed the Treaties of Rome to create the European Economic Community (EEC) and the European Atomic Energy Community (EAEC) . They undertook to eliminate the trade barrier among themselves by forming a common market. In 1967, the three communities (ECSC, EEC and EAEC) formally merged into the European Community (EC), creating a single Commission, a single Council of Ministers, and the body known today as the European Parliament.
Membership of the EC expanded from the original 6 to 12 members between 1973 and 1986 (with new members Denmark, Ireland, United Kingdom, Greece, Spain and Portugal). In 1992, they signed the Treaty of Maastricht which laid the basis for further forms of cooperation in foreign and defense policy, in judicial and internal affairs, and in the creation of an economic and monetary union - including a common currency. This further integration created the European Union (EU) in 1995. 3 new members, Austria, Finland and Sweden, joined in the same year.
On January 1, 1999, one of the largest steps toward European unification took place with the introduction of the euro as the official currency in the EU. Euro became the unit of exchange for most EU countries except United Kingdom, Denmark and Sweden who decided not to convert their currencies to Euro.
The EU continued to expand with 10 more countries - Cyprus, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Malta, Poland, Slovakia and Slovenia, joining in 2004. Later in 2007, 2 other countries, Bulgaria and Romania, joined, bringing the total membership to 27 where it stands today (Nov2011).
As of now, members of the EU (27) include:
Austria (1995), Belgium (1951), Bulgaria (2007), Cyprus (2004), Czech Republic (2004), Denmark (1973), Estonia (2004), Finland (1995), France (1951), Germany (1951), Greece (1981). Hungary (2004), Ireland (1973), Italy (1951), Latvia (2004), Lithuania (2004), Luxembourg (1951), Malta (2004), Netherlands (1951), Poland (2004), Portugal (1986), Romania (2007), Slovakia (2004), Slovenia (2004), Spain (1986), Sweden (1995), United Kingdom (1973).
Only 17 of the 27 members of the EU are part of the Eurozone, the name for the collection of EU countries that utilize the euro. Except United Kingdom, Denmark and Sweden, other new members are working toward becoming part of the Eurozone. Eurozone members (17) include:
Austria, Belgium, Cyprus, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Malta, Netherlands, Portugal, Slovakia, Slovenia, Spain.
The EU's mission is to:
. guarantee peace, freedom and security in and around Europe
. promote and protect democracy and universal rights in Europe and around the world
. strengthen Europe's economy and to promote solidarity around Europe by working in partnership with national, regional and local government
. make it easy for Europe's citizens to live and work throughout the Union
. promote equality and tolerance of diversity in Europe
. promote and facilitate cooperation between Europeans, at individual, local, regional and national level, and in both the public and private sectors
. protect Europe's environment
. ensure that Europe's voice is heard in the world
. listen to its citizens, be accountable to them and work for them in a transparent and decentralised way.
The EU has its own official flag. It consists of a circle of 12 golden stars on a blue background. The number of stars (12) represents completeness while their position in a circle represents unity. The EU adopts Beethoven's Symphony Number 9 'The Ode of Joy' as their official anthem, conveying the idea of freedom, peace and unity.
(extract from http://www.youtube.com/watch?v=vXuhvzbQ5EI&feature=related)
Wednesday, November 2, 2011
The Fox and the Vineyard
The moral, from one perspective - 'We come with nothing and we leave with nothing. We can't take away any fame and fortune we accrued in life. So, don't take it too serious.'
Or perhaps we look from the other perspective - 'Sometimes it's not the result we should bother, but rather it's the process we should enjoy.'
Wednesday, October 26, 2011
The Secrets of Life (3) - Genes and Health and Development
If some of the chemical bases in the sequence in the gene is changed, a gene mutation (基因突變) occurs. In this case, the normal genetic sequence in the gene is disturbed, causing the gene either not to function or function incorrectly, and hence the gene becomes faulty. Gene mutation may occur in several ways:
A. Spelling change - some chemical bases ('letters') in the genetic sequence are changed.
B. Insertion - extra 'letters' are inserted in the genetic sequence.
C. Deletion - some 'letters' are deleted from the genetic sequence.
D. Repetition - some 'letters' are repeated in the genetic sequence.
|
| Correct sequence | Faulty sequence |
| A. Spelling change | TAG GCC CAG CAG TCA CTG | TAG GCC CAG CAG TAA CTG |
| B. Insertion | TAG GCC CAG CAG TCA CTG | TAG GCC CAG CAG TCC TCA CTG |
| C. Deletion | TAG GCC CAG CAG TCA CTG | TAG GCC CAG CAG CTG |
| D. Repetition | TAG GCC CAG CAG TCA CTG | TAG GCC CAG CAG CAG CAG TCA CTG |
1. the faulty genes in the chromosomes are inherited from parents
2. the genes become faulty during the formation of the egg or the sperm
3. the genes become faulty during the lifetime of the individual (e.g. due aging or exposure to radiation etc.)
As genes are in pairs, sometimes a faulty gene in a chromosome may not cause any problem as there is still another working copy of the gene in the other pair of the chromosome. In fact, all normal human usually has several faulty genes in the body at any times, and the body still functions normally. Only that if both copies of the same gene in both pair of chromosomes are faulty, then genetic problem occurs. Sometimes, the fault in a gene is so severe that even there is a working copy of the gene in the other pair of the chromosome, it will still cause genetic problem. Such kind of faulty gene is said to be dominant.
Some examples of common genetic problems due to faulty genes are listed as follows:
| Disease | Gene | Symptom |
| Cystic fibrosis (囊腫性纖維化) | CFTA in chromosome 7 | Salty tasting skin, frequent chest infection and coughing or shortage of breath, poor growth and weight gain despite normal food intake |
| Haemophilia (血友病) | Factor 8 in X chromosome | Continued bleeding due difficulty to clot. |
| Thalassemia (地中海貧血症) | HBA1/2 in chromosome 16 | Ranges from no problem to severe depending on number of genes affected, anaemia (貧血) when severe. |
| Breast cancer (乳癌) | BRCA1 in chromosome 17 BRCA2 in chromosome 13 | Breast lump, change in breast size and shape, inverted nipple |
| Alzheimer (老人癡呆症) | PS1 in chromosome 14 PS2 in chromosome 1 | Difficulty with memory, learning, thinking and reasoning, and undertaking everyday tasks, usually associated with aging. |
| Parkinson (帕金森病) | PARKIN in chromosome 6 | Tremors, stiffness of muscles and slow movements |
The above gives some simplistic views on how changes in genes affect the health and development of individuals, in as much as changes in chromosomes do. It is recommended that affected individuals should seek professional advice from genetic counseling on details of medical issues, and implications on any possible inheritance issues when considering births of offspring .............................
Thursday, October 20, 2011
某年, 某月, 某曰 寫於羅省機埸
我欲乘機歸去
又恐隨時 off - load
心底不勝寒
此詞寫出一般航空公司職員 (及其家屬), 手持(staff standby) 機票於登機櫃枱前百感交雜之心情; 其中包括: 期待, 渴望, 無助, 無奈, 失落, 擔憂, 抑鬱, 焦慮, 惶恐, 希斯底里, ............................
註 : offload
一般航空公司職員 (及其家屬), 享有特別優惠價錢的(staff) 機票. 惟亦需遵守侯補(standby) 登機之條件. 每次辦理登機手續後, 需於登機櫃枱前等候. 待所有其他乘客完成登記程序, 點算剩餘機位, 才可陸續登機. 假若機位不足, 便不接受上機, 是為 offload.
Monday, October 10, 2011
The Fables of Aesop (伊索寓言) - The Wind and the Sun
Moral : 'Kindness can be more effective than force.'
